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Btw, crosslinking HA was developed for dermal fillers (as crosslinking helps their longevity), and this guy is the topical version of FDA approved dermal filler called Hylan B gel

The results showed that EODF significantly reduced hippocampal CA3 region neuronal loss, and Morris water maze tests (latency, exploration trials) showed significant differences between the EODF and AL groups, suggesting that 23 months of EODF could significantly reduce kainic acid-induced hippocampal damage and visuospatial memory impairment