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Treatment plans are individualized, and long-term use is determined by a medical practitioner based on health goals and progress

Weight-Related Conditions People with obesity-related conditions, such as type 2 diabetes or metabolic health concerns, are also being studied to understand potential benefits

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Here we report the engineering and preclinical development of a bimodal molecule that integrates NMDA receptor antagonism with glucagon-like peptide-1 (GLP-1) receptor agonism to effectively reverse obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease