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How GLP-1 Medications Work in the Gut These drugs slow gastric emptying, help people feel fuller longer, and can reduce overall food intake, which is why they may be effective for weight loss, says Danielle Gaffen, RDN, the San Diegobased founder of Eat Well Crohns Colitis, which provides personalized nutrition counseling for people living with IBD and other digestive conditions

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However, no completed trial has examined the effect of GLP-1 RAs on cardiovascular events in patients with established CVD and overweight/obesity in the absence of type 2 diabetes