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However, one should bear in mind that Ebselen and other GPx mimics may cause various side effects and affect the cellular redox state

Yet, the foundation of these claimsits supposed resilience to degradation in its arginine salt formdemands a thorough examination against the backdrop of biochemical principles and empirical evidence

Early mutagenesis studies of the Arabidopsis GS identified a putative glycine-rich loop as important for activity (Wang and Oliver, 1997a,b), which was identified in later structural studies as forming part of the active site (Galant et al., Arabidopsis GS uses a random Ter-reactant mechanism with binding of either ATP or -glutamylcysteine preferred first and addition of glycine last (Jez and Cahoon, Arabidopsis GS and for the eukaryotic homologs (Herrera et al., 2+ to ATP and orienting the -phosphate group in the active site

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