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The method has the advantages that Fmoc-Lys (Alloc)-OH protection amino acid is used as a raw material, de-protection is carried out by the aid of selected Pd (PPh3) 4, accordingly, operation procedures are simple, only 1-2 times of simple elimination reaction operation are required, each elimination reaction operation is carried out for 10-30 min, side reaction is prevented, the operation procedures are safe, and enlarged production can be facilitated

This can be inconvenient for some patients

The results showed a significant reduction in pigmentation lesions, as measured by the modified MASI score, compared to placebo

However, only in about 17% of human patients, GCP-R stimulation induced a PIE (Wallner et al