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Best Practices for Taking Supplements with Weight Loss Medications When combining any supplement with prescription weight loss medication like Wegovy, following evidence-based best practices helps optimise safety and effectiveness: Inform your healthcare team : Always disclose all supplements, vitamins, and over-the-counter products you take to your GP, prescribing clinician, or pharmacist

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And in your brain particularly in the hypothalamus GLP-1 delivers satiety signals, dialing down food-seeking behavior

Elevated fatty acids (FAs) activate Toll-like receptors (TLRs) in macrophages, which act in synergy with MSU crystals to trigger NLRP3 inflammasome activation and pro-inflammatory cytokine release (e.g., IL-1), thereby initiating the inflammatory cascade