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11 Interestingly, the antidepressant effects of ALC appeared most robust in older adults, suggesting age-related differences in mitochondrial or neurochemical pathways might mediate its psychotherapeutic actions

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As summarized in Table 1, macrophages, T lymphocytes, and vascular wall cells, through their distinct bidirectional immunometabolic regulatory networks, predominantly drive the formation of the inflammatory microenvironment, immune imbalance, and vascular remodeling, thereby promoting the diseases pathological progression