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Inflammatory cytokines notably interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-) play a critical role in plaque progression and instability, increasing the risk of plaque rupture and acute events such as myocardial infarction and stroke [34]

But it seems growing evidence from cell and animal models of the disease suggests there's some kind of connection here

In severe cases, it can cause sepsis, organ failure and death

Blood test markers to discuss with a clinician Marker CBC with differential Why it matters Screens anemia, infection patterns, and general blood-cell context before interpreting fatigue changes