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Therefore, as an autoimmune disease, GD can cause systemic immune activation and high levels of inflammatory factors in the circulation, leading to the activation of the HPA axis and hypersecretion of related hormones

The actions of adiponectin in suppressing gluconeogenesis and enhancing lipid oxidation are related to the activation of adenosine monophosphate-activated protein kinase (AMPK) and the inhibition of acetyl-CoA carboxylase (ACC) in liver and muscle (Yamauchi et al., 2002)

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An injectable treatment could make the issue worse and increase the risk of side effects