Common side effects include: Nausea and vomiting, especially at the start of treatment Gastrointestinal discomfort, such as bloating, diarrhea, or constipation Injection site reactions like redness, swelling, or itching Loss of lean muscle mass along with fat loss Dysesthesia, which includes tingling and skin sensitivity, is reported in as many as 20.9% of patients on higher doses
It leads to changes in the structure of skin matrix proteins, such as collagen and elastin, and consequently, to loss of skin elasticity and firmness, the formation of wrinkles, and pigmentation disorders (116118)
Place towels on the cooling packs to avoid direct contact with the injection pens
Contrave (naltrexone/bupropion) is the most affordable option at approximately $254 per month at the maintenance dose