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The indications for the use of GLP1-RA in the study included weight loss (n=117, 70%), diabetes (n=46, 28%) and other indications (n=4, 2%) such as PCOS, dumping syndrome or metabolic syndrome (online supplemental figure 1)
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Tirzepatide, the active ingredient in Lillys Mounjaro and Zepbound, works similarly while also acting on another class of receptors known as gastric inhibitory polypeptide (GIP) receptors
Tirzepatide at the doses of 10 and 15 mg was noninferior to insulin degludec (primary endpoint) and all three doses of tirzepatide demonstrated superiority in comparison to insulin degludec regarding the change in HbA1c
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