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Hunter 2013)

Clinical trials (SURMOUNT-1) demonstrate that patients taking the maximum weekly dose of 15mg achieved an average of 22.5% body weight reduction (equivalent to 22.5kg lost for a 100kg baseline) over a 72-week course when paired with supportive dietary and exercise changes

24 Patients with subtype C disease have significant immune cell infiltration and proinflammatory features, especially a significant increase in the activity of immune cells such as lymphocytes and macrophages

However, despite these promising findings, the potential role of GLP-1RAs in PsA, particularly as a dual-action agent targeting both metabolic and immune dysregulation, remains insufficiently explored