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Written by Jay Hastings | Reviewed by Jayden Lee, PharmD | Last updated May 14, 2026 | Last reviewed May 14, 2026 Semaglutide side effects can start within the first few days after treatment begins, although some people do not notice symptoms until their dose increases

It says a provider should assess thyroid status, review current medications, and set a monitoring plan first, and that baseline TSH, free T4, and thyroid antibody testing may be warranted when the thyroid history is unclear

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