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Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

We identified subcomplexes including the DDD and the DDD-Ube2e2 complex, resolved to 3.25 and 3.26 resolution respectively (Supplementary Fig.3C), as the two predominant populations, as well as a fraction containing two copies of COP1 bound to one single DDD-Ube2e2 complex, which was resolved to 3.62 resolution based on FSC analysis (Supplementary Figs