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This is confusing as individuals with painful lipomas in an FML family have been described as having Dercum disease

Precisely, inclusion was considered for original research articles investigating genome-wide DNA methylation or at a regional scale in patients with clinically confirmed endometriosis (surgery and/or histological examination), whatever the disease severity (stages IIV, ASRM classification [20])

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Thereby, it is possible to uncover activities of extract constituents at particular cellular signal transduction pathways after interacting with target molecules, e.g., receptors or enzymes