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If weight loss continued despite these adjustments, a blinded dose reduction of the study drug could be considered

How GLP-1 Medications Affect the Biliary System GLP-1 receptor agonists can change the biliary system in several ways

Hence, GLP-1RAs can be utilized as an adjunct alongside metformin as a first-line treatment for type 2 DM or, in specific cases, as a preferred therapeutic agent when additional benefits for cardiovascular or renal protection are required [84]