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Phase 2 trials are primarily designed to assess dose-response relationships and safety signals rather than to definitively establish efficacy at a population level

They characterise GH and IGF-1 elevation but do not measure fat mass, lean mass, or any other outcome that gym-focused users care about

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However, high doses of vitamin A appear associated with reduced bone density and increased fracture risk by inhibiting osteoblast activity (Yee et al, 2021)