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The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

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At the molecular level, chronic AOD9604 administration upregulates 3 adrenergic receptors in fat tissue, reversing obesityrelated suppression of these fatburning receptors [9]