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Siddique S, Matera C, Radakovic ZS, Shamim Hasan M, Gutbrod P, Rozanska E, et al

The 2020 systematic review by Galeano and colleagues across 34 eligible studies confirmed the mechanism: PDRN promotes physiological tissue repair through salvage-pathway nucleotide recycling and A2A receptor activation [32]

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We do not have human outcome data, the long-term safety of cumulative copper loading is uncharacterized, and the vials being injected are mostly research-grade products from unregulated suppliers with no sterility guarantee