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Another meta-analysis also demonstrated that GLP-1s have a robust effect in reducing MACE (RR 0.87

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[19] United States [edit] In the United States, semaglutide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes, [13] [14] and to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease