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Frontiers in Endocrinology, 14(1326546)

The potential benefits come packaged with real risks, from insulin resistance concerns to unknown long-term interactions that no researcher can currently predict

Gilead Sciences last year dropped a Phase II (NCT04971785) program to develop the Nimbus-discovered acetyl-CoA Carboxylase (ACC) inhibitor firsocostat (formerly GS-0976 and NDI-010976), in combination with semaglutide and another Gilead candidate, cilofexor, in cirrhosis due to metabolic dysfunction-associated steatohepatitis (MASH)

Sustainable behavioural change The medication helps patients reset their relationship with food, but long-term success depends on gradual habit building