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Simultaneously, semaglutide suppresses glucagon secretion from pancreatic alpha cells primarily during hyperglycemia, while generally preserving counterregulatory glucagon responses during hypoglycemia
It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)
Li Y, Vaughan KL, Tweedie D, Jung J, Kim HK, Choi HI, et al
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