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Some lean mass loss can occur during any weight loss, but muscle preservation is possible through proper nutrition and exercise

These trials, including the PIONEER (Peptide Innovation for Early Diabetes Treatment) 2 trial, used oral semaglutide rather than injectable semaglutide and found that standard doses of up to 14 milligrams (mg) of oral semaglutide were safe and effective when combined with daily metformin doses of at least 1,500 mg

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