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During PF progression, there is a close relationship between the TGF-1/Smad signaling pathway and ROS generation ( 3.3 Inhibition of PUFAs peroxidation Lipids containing diallyl carbons and PUFAs are highly susceptible to lipid peroxidation, which can induce ferroptosis ( ACSL4, a key gene in ferroptosis, can facilitate this process, leading to iron overload and enhanced lipid peroxidation within cells, which, in turn, causes cellular damage and death

This naturally occurring compound is found in nearly every cell in the body, helping to protect against oxidative stress and promote overall well-being

These microbial alterations were accompanied by functional impairments, with CMS significantly reducing SCFA production, particularly acetic and propionic acid concentrations (Tyagi et al., 2025)