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Thus, we hypothesize that NO might contribute to the schistosomula metabolic transition by inhibiting respiration [11, 14, 68, 69] and promoting anaerobic metabolism associated with increased production of lactate [70]
It is reported that high concentrations of fumarate and succinate can enhance the 3-methylation of histones H3K4 and H3K27 by inhibiting KDM5 histone demethylase (responsible for H3K4 demethylation) and JMJD3 histone demethylase, respectively, which in turn promotes the expression of pro-inflammatory cytokine genes (99, 115, 125, 161, 162)
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