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Metformin also induced a G1-cell cycle arrest and apoptosis in EML 4 -ALK(+) lung cancer (H3122) cells partly through the modulation of IGF-1 expression (23)

Thats one of the reasons some people prefer newer GLP-1 medications like semaglutide (Ozempic and Wegovy) or tirzepatide (Mounjaro and Zepbound), which only require one weekly injection