Luz del Mar et al., 2023, studied the effect of cocoa polyphenol extract against reactive stress-induced cellular senescence, showing that there was an attenuation of senescent phenotypes and oxidative DNA damage, reducing mitochondrial dysfunction by inhibiting the generation of mitochondrial ROS (mtROS)
Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN (2001) Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Abstract Transdermal delivery of peptide drugs is almost impossible with conventional penetration enhancers because of epidermal barrier function
That level of personalized attention allows treatment to go deeper than surface-level coping strategies