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By modifying the primary sequence of OXM and linking to the constant region of human IgG4, Jung and colleagues demonstrated their peptide HM12525A had a potent and balanced activity at both GLP-1 and glucagon receptors in vitro and led to body weight loss of 30% in DIO mice over 14 days compared to liraglutide treated mice (74)

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VrintsCAndreottiFKoskinasKCRosselloXAdamoMAinslieJet al2024 ESC guidelines for the management of chronic coronary syndromes

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