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Role of ROS in UV-induced photodamage of the skin Normal skin tissue mainly includes keratinocytes in epidermis, melanocytes near the basement membrane, fibroblasts in dermis and some extracellular matrix

Due to this high aerobic demand, the generation of high amounts of ROS and other oxidative by-products is unavoidable ( GSH is synthesized via two ATP-dependent enzymatic steps catalyzed by glutamate-cysteine ligase (GCL) and glutathione synthetase

Since 1995, numerous studies have demonstrated curcumins ability to inhibit and reduce the proliferation of colorectal cancer cells (537, 538)

Angiogenesis is the formation of new blood vessels