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Thoughtful individualization based on patient characteristics, systematic titration allowing tolerance development, and systematic monitoring enables development of personalized protocols delivering optimal outcomes within each individual's physiologic capacity and treatment goals

Increased infiltration of local neutrophil extracellular traps (NETs) around intestinal microvasculature, accompanied by increased ferroptosis of endothelial cells, was detected in both intestinal I/R patients and animal models, which may be a major cause of microcirculation dysfunction

These findings have been interpreted as suggesting potential protective cellular processes, though precise implications remain under review

Its created by muscle functions and is a byproduct of muscle creatinine phosphate