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Based on the present steady-state data, we compared the developed population PK model to a one-compartment PK model similar to the one estimated in the phase 3 analysis [6] with almost identical results

The overall eye outcomeassessed at the end of treatment by a change in a composite score including exophthalmometry, clinical activity score (CAS), measurement of eyelid aperture, diplopia and visual acuityas well as the quality of life were significantly better in the selenium group

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