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In the future, large cohort studies investigating high-risk HLA alleles could also permit irAE risk profiling of patients in advance of ICI treatment, and allow physicians to adjust treatment plans, or intensity of surveillance, based on these risk models

Along with the counteracted ECG disturbances, intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension were eliminated/attenuated [80]

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Allergy or Mast-Cell Histamine Release Hives, itching, swelling, wheezing, rhinitis or reactions to allergens, temperature, medications or other triggers may reflect immune-cell activation rather than food histamine alone