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A Caco-2 bidirectional transport assay showed an apparent permeability (P app ) of 34.2 10 6 cm/s from apical to basolateral and 45.2 10 6 cm/s from basolateral to apical, with an efflux ratio of 1.33, indicating high permeability and no significant efflux

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The only other RCT that investigated the effect of selenium supplementation on AITD in pregnancy found no difference in the magnitude of TPO-antibody decrease between selenium and placebo groups ( Reference Mao, Pop and Bath 98 )