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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies

In the mitochondrial matrix, tricarboxylic acid cycle (TCA) enzymes generate electron carriers such as NADH and FADH2, which donate electrons to the electron transport chain (ETC) in the IM

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