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Here, we systematically review the hepatoprotective activity and molecular mechanisms of the natural products that are found to counteract the hepatotoxicity caused by APAP, providing reference information for future preclinical and clinical trials of such natural products

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Our analysis identified multiple metabolic pathways that were altered in both 3xTg CR-fed and DL-fed females, including downregulation of pathways involving the metabolism of amino acids including Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, and Pentose phosphate pathway (Fig