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Clinical and observational data, while still limited in scope and heterogeneity, support the translational potential of these findings
Under normal conditions, cells generate ATP (adenosine triphosphate), the primary energy currency, by oxidizing both fatty acids and glucose
The brain avoids ammonia toxicity by converting -ketoglutarate into glutamate and glutamine synthesis
GLP1 receptor agonists (GLP1RAs) are established treatments for type 2 diabetes mellitus (T2DM) and obesity, with data that support positive effects on hard clinical end points such as cardiovascular events and renal outcomes
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