The UK MHRA issued a public advisory in November 2008 that MT-II is an unlicensed medicine and supply is illegal under the Medicines Act 1968, triggered by 18 adverse-event reports detailing 74 separate reactions
3 Semaglutides limited supply and insurance coverage, including coverage prohibitions for weight loss drugs in Medicare Part D and coverage restrictions (prior authorization, nonpreferred status, or step therapy) in many state Medicaid plans, 4,5 may contribute to barriers and disparities in accessing semaglutide due to its high out-of-pocket costs
This work was supported by the National Natural Science Foundation of China (81790640, 32070989, 31872766, 31571075, 82070993, and 31571072), the Ministry of Science and Technology of China (2011CB504602 and 2015AA020512), Shanghai Municipal Science and Technology Major Project (2018SHZDZX01), ZJLab, Shanghai Center for Brain Science and Brain-Inspired Technology, and Sanming Project of Medicine in Shenzhen (SZSM202011015)
Individuals with preexisting heart conditions, such as arrhythmias or hypertension, should use semaglutide cautiously and under medical supervision, as metabolic changes can sometimes impact heart rhythm
