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Cancer 122 , 279292 (2020)

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If you must store reconstituted solution for a brief period of time: Keep the vial in the refrigerator at the temperatures indicated Protect the vial from all light in an amber vial, and for no longer than the timeframe specified by your compounding pharmacy (typically 24 hours maximum) Do not freeze reconstituted solution, as freeze-thaw cycles destroy potency while introducing aggregation risk Route-Specific Glutathione Considerations Intravenous IV-administered GSH increases plasma glutathione transiently, but please know extracellular GSH is rapidly degraded by the enzyme gamma-glutamyltransferase (GGT) (this limits reliable elevation of intracellular GSH levels)