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The evidence regarding its impact on oxidative stress in migraine models remains limited, underscoring the need for careful consideration of dosages of topiramate and application conditions in the prophylactic treatment of migraines

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Mature BDNF binds with high specificity to the tropomyosin-related kinase receptor type B (TrkB) (26) and to the low-affinity neurotrophin receptor p75, then exerts its actions via interactions between these two trans-membrane receptors, separately or in collectively, potentially leading to neuronal death or survival

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