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Fluoxetine-induced androgen deficiency may lead to the increased expression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1), which activates the pro-apoptotic factor p53 through deubiquitination and triggers germ cell apoptosis

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A unique reactive astrocyte specific to AD, termed DAA when transcriptomically defined (Liddelow et al., 2017), has been positioned near A-plaque and DAM (Figure 3B