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Bedtime dosing works well because sleep represents a natural fasted state

The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure

[4] [6] In clinical contexts, high-dose intravenous ascorbic acid may modulate immune function, enhance wound healing, and support endothelial integrity

Moreover, research has demonstrated that cobalamin is not only essential to this process but also actively promotes the expression and synthesis of the components necessary for the formation and repair of the myelin sheath [76]