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232 , R1R26 (2017)

APAP feeding resulted in a significant decrease in total glutathione levels relative to vehicle control, with greater than a 70% reduction in total GSH levels after 3 days of exposure (116.42 5.55 uM GSH for vehicle control vs 33.67 2.35 for APAP treated)

This leads to the activation of immune cells (e.g., T cells, B cells, NK cells, monocytes/macrophages) and dysfunction of glial cells, culminating in the release of pro-inflammatory cytokines and complement components such as C4

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