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Semaglutide lowers blood pressure via GLP-1 receptors on vascular smooth muscle, not via endothelial or immune pathways

But its still important to confirm that dual agonist drugs like tirzepatide can offer similar or even potentially greater cardiovascular benefits (in theory, it was possible that one of the ingredients could have negatively affected the heart)

A 2021 randomized controlled trial demonstrated that exenatide, a GLP-1 receptor agonist, significantly slowed cognitive decline in patients with early-stage Parkinsons disease compared to a placebo group (Athauda et al., 2021)

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