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Spectra scans were acquired in Q-Exactive mass spectrometry instrument (Thermo Scientific, USA), coupled to a nano UHPLC system via a nanoelectrospray ion source

The ruthenium(II)arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53JNK pathways

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Besides, biologics have a high degree of specificity and affinity for therapeutic receptors owing to the extensive area of interaction with targets through established motifs, but they suffer from low cellular membrane permeability, poor oral bioavailability, and metabolic instability, resulting in limited intracellular applications [13, 14]