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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology ( As many treatments for neurological conditions have been hampered by limited permeability of the BBB, significant emphasis has been placed on research directed towards advanced drug delivery methods (Zha et al., 2024

389, n o 24, 22212232 (ISSN 0028-4793 et 1533-4406, DOI 10.1056/NEJMoa2307563, lire en ligne, consult le Cet essai clinique en double aveugle, a compar le smaglutide un placebo, chez les patients adultes obses traits par 2,4 mg de smaglutide par semaine par voie sous-cutane

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