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Furthermore, GLP-1RAs produced through biological manufacturing techniques must abide by stringent regulatory standards, including the Good Manufacturing Practices, which are strictly enforced, which further increases the complexity and cost of these production processes as continuous monitoring, documentation, and validation of the processes are required

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However, another study showed that the NK1R antagonist L822429 reduced progressive ratio responding for alcohol by P rats, but not by Wistar rats (Schank et al., 2013)