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The most effective approaches at this age are naturalistic, play-based and family-centred such as the Early Start Denver Model and DIR/Floortime combined with speech therapy and occupational therapy

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Although previous studies have identified an association between COC use and a small increase in breast cancer risk 39,40 our results suggest that the mechanisms mediating this may not involve depurinating estrogen DNA-adduct formation

Identity and purity of every batch - including HPLC purity, appearance, and relevant physicochemical parameters - are documented on the lot-specific Certificate of Analysis, available on request to support formulators' own specification and QC programs