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For the highest dose group (12 mg), this is what the titration schedule looked like: Weeks 1-4 : 2 mg once weekly Weeks 5-8 : 4 mg once weekly Weeks 9-12 : 8 mg once weekly Weeks 13 onward : 12 mg once weekly What phase 3 trials show so far: Testing long-term dosing of retatrutide In more recent phase 3 trials , the doses used are a bit different, but the overall structure still follows that same gradual, step-by-step pattern

Improvements in physical function mirrored pain results, with WOMAC physical function scores improving by more than 70% in retatrutide-treated participants

For example, studies involving GLP-1 RAs have been shown to reduce major adverse cardiovascular events in patients with T2DM