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The causes of GLP-1 agonist side effects include: GLP-1 side effects are more noticeable at certain times: Most patients who take GLP-1 drugs tolerate them well

Last reviewed: June 5, 2026 Last updated: June 5, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

It can increase the thermogenesis and utilization of triacylglycerol-derived fatty acids and glucose in brown adipocytes and reduce the lipid content through the central GLP-1R agonists signaling pathway, such as central AMP-activated protein kinase or sirtuin-1 (SIRT1), also known as NAD-dependent deacetylase SIRT1 (3639)

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