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10.1016/j.cell.2018.10.001 47 KalamkarS.AcharyaJ.Kolappurath MadathilA.GajjarV.DivateU.Karandikar-IyerS.et al (2022)

doi: 10.4103/ijmr.IJMR_1144_16 138 JauhariABaranovSVSuofuYKimJSinghTYablonskaSet al

Recognize that these typical stages of development and "ups and downs" may correlate with a new treatment

Patients frequently seek medical attention only after symptoms substantially impair quality of life, by which point tissue injury may be established, such as lupus nephritis in SLE, pericarditis in RA, or thromboembolic complications in Crohns disease [25, 26]